Is What We Want What We Need, and Can We Get It in Writing? The Third-Wave of Feminism Hits the Beach of Modern Parentage Presumptions

Modern statutes on parentage regarding artificial insemination and the cases that have interpreted them reflect the explosion of family gender roles by second-wave feminism. Although a natural father now is generally expected to share the rights and obligations of parentage with a natural mother, this is not so if he is a mere contributor of biological material. Are the modern presumptions underlying such statutes, what we used to want, what we have come to need? Or, is current law too much a reflection of the essentialism for which the second-wave is sometimes justly criticized?Third-wave individualism and resistance to inflexible doctrine supply interesting lenses for an examination of the developing law in this area. Particularly, a recent Kansas 1 case, In the Interest of K.M.H., is the first to evaluate a statute designed to give power to individual choice by making a parentage presumption secondary to an agreement between a woman and a sperm donor that the donor will be treated as a parent.This paper explores the context and outcome of this case and whether we have exhausted the limits of legal reform that can be achieved through the creation of- even progressive - presumptions about parentage. Given the changes wrought under the influence of the second-wave, do such presumptions retain vitality and usefulness? Or, do they produce only a different, but not necessarily better, set of obstacles to formation and preservation of individual families and their informed choices

Commenting on the 'great debate' : general abilities, specific abilities, and the tools of the trade

We review papers in the special issue regarding the great debate on general and specific abilities. Papers in the special issue either provided an empirical examination of the debate using a uniform dataset or they provided a debate commentary. Themes that run through the papers and that are discussed further here are that: (1) the importance of general and specific ability predictors will largely depend on the outcome to be predicted, (2) the effectiveness of both general and specific predictors will largely depend on the quality and breadth of how the manifest indicators are measured, and (3) research on general and specific ability predictors is alive and well and more research is warranted. We conclude by providing a review of potentially fruitful areas of future research

Conditions of the Development of Logistic Centers in Poland in the Context of European States Experiences

The article is, for the most part, the aftermath of his own examinations carried out in years 2007-2010 and concerning logistic centers development conditioning.Artykuł jest w znacznej mierze pokłosiem badań własnych autora przeprowadzonych w latach: 2007-2010 dotyczących uwarunkowań rozwoju centrów logistycznych

The Notch Ligand JAG1 Is Required for Sensory Progenitor Development in the Mammalian Inner Ear

In mammals, six separate sensory regions in the inner ear are essential for hearing and balance function. Each sensory region is made up of hair cells, which are the sensory cells, and their associated supporting cells, both arising from a common progenitor. Little is known about the molecular mechanisms that govern the development of these sensory organs. Notch signaling plays a pivotal role in the differentiation of hair cells and supporting cells by mediating lateral inhibition via the ligands Delta-like 1 and Jagged (JAG) 2. However, another Notch ligand, JAG1, is expressed early in the sensory patches prior to cell differentiation, indicating that there may be an earlier role for Notch signaling in sensory development in the ear. Here, using conditional gene targeting, we show that the Jag1 gene is required for the normal development of all six sensory organs within the inner ear. Cristae are completely lacking in Jag1-conditional knockout (cko) mutant inner ears, whereas the cochlea and utricle show partial sensory development. The saccular macula is present but malformed. Using SOX2 and p27(kip1) as molecular markers of the prosensory domain, we show that JAG1 is initially expressed in all the prosensory regions of the ear, but becomes down-regulated in the nascent organ of Corti by embryonic day 14.5, when the cells exit the cell cycle and differentiate. We also show that both SOX2 and p27(kip1) are down-regulated in Jag1-cko inner ears. Taken together, these data demonstrate that JAG1 is expressed early in the prosensory domains of both the cochlear and vestibular regions, and is required to maintain the normal expression levels of both SOX2 and p27(kip1). These data demonstrate that JAG1-mediated Notch signaling is essential during early development for establishing the prosensory regions of the inner ear

Mantle heterogeneity controls on small-volume basaltic volcanism: Reply

Artículo de publicación ISIEruptions of basaltic material in small-scale volcanic fields located in intraplate settings display a very diverse range in physical and chemical characteristics. Despite its relevance to the understanding of volcanic hazards, the relationship between physical properties of eruptions (explosivity, volume, location) and chemical composition of erupted products has, to date, not been investigated. Here we present a relationship between mantle heterogeneity and extents of partial melting, and both erupted volumes and eruptive style from the Auckland Volcanic Field (New Zealand), and we suggest that this provides a general model for small-scale "monogenetic" magmatic systems globally. Small volcanic centers consistently take the form of nephelinitic tuff rings and scoria cones, whereas larger centers are produced from effusive eruptions of less alkalic magmas. Nephelinitic melts are generated by melting of a deep, carbonated source, whereas less alkalic melts are the products of melting of a shallower, noncarbonated source. U-Th-Ra isotope data from eruptions closely paired in space and time show that mixing between magmas is extremely limited as a consequence of different ascent mechanisms due to differential segregation of melts from varying sources (early, carbonated melts ascending by higher porosity channels, and later, uncarbonated melts by a more diffusive regime). This suggests that extraction of melt is nearly instantaneous in these environments. Our results stress the importance of melting and magma dynamics in determining the size and style of eruptions in small volcanic fields, and suggest that mantle controls should be an important consideration in volcanic hazard assessment.Centro de Excelencia en Geotermia de los Andes (CEGA, Chile) by FONDAP (Fondo de Financiamiento de Centros de Investigacion en Areas Prioritarias) 1509001

A Comprehensive Molecular Interaction Map for Rheumatoid Arthritis

Computational biology contributes to a variety of areas related to life sciences and, due to the growing impact of translational medicine - the scientific approach to medicine in tight relation with basic science -, it is becoming an important player in clinical-related areas. In this study, we use computation methods in order to improve our understanding of the complex interactions that occur between molecules related to Rheumatoid Arthritis (RA).Due to the complexity of the disease and the numerous molecular players involved, we devised a method to construct a systemic network of interactions of the processes ongoing in patients affected by RA. The network is based on high-throughput data, refined semi-automatically with carefully curated literature-based information. This global network has then been topologically analysed, as a whole and tissue-specifically, in order to translate the experimental molecular connections into topological motifs meaningful in the identification of tissue-specific markers and targets in the diagnosis, and possibly in the therapy, of RA.’

Toward high-precision values of the self energy of non-S states in hydrogen and hydrogen-like ions

The method and status of a study to provide numerical, high-precision values of the self-energy level shift in hydrogen and hydrogen-like ions is described. Graphs of the self energy in hydrogen-like ions with nuclear charge number between 20 and 110 are given for a large number of states. The self-energy is the largest contribution of Quantum Electrodynamics (QED) to the energy levels of these atomic systems. These results greatly expand the number of levels for which the self energy is known with a controlled and high precision. Applications include the adjustment of the Rydberg constant and atomic calculations that take into account QED effects.Comment: Minor changes since previous versio